Gene regulatory networks are one of the main cellular infrastructures that confer defined biological functions. Our research focuses on synthetic and systems biology - the analysis, construction, and exploitation of these regulatory networks for cellular functionality reprogramming. In particular, we are interested in understanding the architecture and dynamics of naturally existing networks, primarily those in bacteria, and exploring their relationship to cellular function. We are also interested in engineering gene circuits for biomedical applications. Along that line, engineered probiotics and microbial consortia are particularly attractive to us. To pursue our interest, we often employ an integrated approach that combines mathematical modeling with experimental synthetic biology.