Gene circuits design and construction; mathematical modeling of bacterial gene regulation; development of synthetic microbial consortia; probiotic bacteria for therapeutic applications.
Gene regulatory networks are one of the main cellular infrastructures that confer defined biological functions. Our research focuses on synthetic and systems biology - the analysis, construction, and exploitation of these regulatory networks for cellular functionality reprogramming. In particular, we are interested in understanding the architecture and dynamics of naturally existing networks, primarily those in bacteria, and exploring their relationship to cellular function. We are also interested in engineering gene circuits for biomedical applications. Along that line, engineered probiotics and microbial consortia are particularly attractive to us. To pursue our interest, we often employ an integrated approach that combines mathematical modeling with experimental synthetic biology.
B.S., 2002, Zhejiang University (Physics)
Ph.D., 2007, University of California at San Diego (Biophysics)
Postdoc., 2007-2011, Princeton University, Massachusetts Institute of Technology, Wyss Institute at Harvard University
National Scientist Development Grant, American Heart Association, 2012
NARSAD Young Investigator Award, Brain & Behavior Research Foundation, 2014
NSF CAREER Award, 2015
ONR Young Investigator Award, 2016