The laboratory of Dr. Yang Liu focuses on developing multiscale optical microscopy techniques, spanning from nanoscale to mesoscale, to advance precision medicine. We work on improving the imaging speed, throughput and precision of label-free quantitative phase imaging (QPI) and single-molecule localization-based super-resolution microscopy, via new instrumentation and computational imaging. We couple label-free high-content imaging of morpho-dynamics with highly multiplexed fluorescence and super-resolution imaging to study a broad range of biophysical properties of chromatin organization, nuclear lamina, and nuclear pore complex in normal and pathological states and understand how cancer initiates and how cancer cells develop resistance as a response to therapeutic agents.