Development of imaging and optogenetic methods to delineate molecular mechanisms underlying cell fate determination; analysis of disrupted protein trafficking in neurodegenerative disorders.
- Biomolecular Structure and Dynamics
- Multiscale Imaging and Visualization
- Synthetic Biology
- Systems Biology
My laboratory studies how signal transduction regulates cell fate determination and how normal signaling processes are compromised in disease conditions. Using live cell imaging and optogenetic control of signal transduction, we observe and perturb signaling modules to define cellular responses. Our major goal is to gain insight into signaling mechanisms that regulate critical cellular functions such as cell proliferation, differentiation, migration, and apoptosis and to apply the insight to understanding and treating neurological disorders.
B.S., 2002, University of Science & Technology of China (Chemical Physics)
Ph.D., 2008, University of California at Berkeley (Chemistry)
Postdoc., 2009-14, Stanford University
American Cancer Society Postdoctoral Fellowship, 2013