The Stadtmueller Lab investigates the assembly, structures and functions of mucosal antibodies in order to understand how these remarkable complexes protect vertebrates from external factors (e.g. pathogens) and how they can be engineered to treat disease. To accomplish this the lab targets data detailing the structures and biophysical mechanisms of mucosal antibodies from different species and mucosal antibody interactions with bacterial and viral antigens and receptors from species such as C. difficle, S. pyogenes, salmonella and influenza A. Common techniques used in the lab include cryoelectron microscopy, X-ray crystallography, surface plasmon resonance and fluorescence microscopy. Together, Stadtmueller lab projects are expanding our understanding of host-microbe co-evolution, antibody structure-function relationships and antibody therapeutic potential.