Research Interest
Aksimentiev, Aleksei

Understanding how the remarkable functionality of biological nanomachines comes about from the spatial arrangement of their atoms and using this knowledge to design synthetic systems that exceed in the performance of their biological counterparts is the focus of this group's research program.

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Anastasio, Thomas

Multilevel modeling of neurobiological systems in health and disease using combined imperative and declarative computational modeling approaches. Current research foci inlcude the molecular and cellular systems underlying Alzheimer Disease, depression, and eating disorders.

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Belmont, Andrew

Our research focuses on basic questions regarding how chromatin folds into interphase and mitotic chromosomes, how chromosomes are organized and move, in some cases over long distances, within interphase nuclei, and how chromosome organization and dynamics impact DNA functions such as transcriptional activation.

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Chemla, Yann

Experimental biological physics, high-resolution optical tweezers, molecular motors, nucleic acid and protein translocases

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Dar, Roy

Systems biology, noise biology, viral and genetic circuitry, HIV, cellular fate-determination and state transitions, drug screening, gene regulation, single-cell biophysics

Das, Aditi

Our lab is interested in the study of the structure-function of membrane proteins involved in the metabolism of omega-3 and omega-6 fatty acids. Our main tools are nanodisc technology, targeted lipidomics, fluorescence spectroscopy, stopped flow spectroscopy, electrochemistry and protein engineering.

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Evilevitch, Alex

My research is in virus biophysics. Specifically, we investigate how physical forces control viral infectious cycles. Since physical forces are often more universal than specific biochemical molecular interactions, this knowledge helps us to understand not just how one type of virus works but how many classes of viruses replicate, providing insight into virus evolution and how to interfere with viral infections in a novel “biophysical” way. Our main tools are solution X-ray and neutron scattering, atomic force microscopy, ultra-sensitive microcalorimetry and fluorescence microscopy.

Fratti, Rutilio

We are interested in how the lipids of a membrane regulate the function of membrane proteins such as SNAREs, Rab GTPases and ABC transporters.

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Gerlt, John

Mechanisms of enzyme-catalyzed reactions, functional genomics, lignin deconstruction for biofuel production: the importance of chemistry in the evolution of new enzymatic activities

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Grosman, Claudio

My laboratory is broadly interested in the relationship between structure and function in neurotransmitter-gated ion channels, with special emphasis on the Cys-loop superfamily of synaptic receptor-channels. Our main tools are single-channel and ensemble electrophysiology, and protein-engineering techniques.

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Gruebele, Martin

Fast protein folding dynamics in vitro and in vivo studied by laser-induced temperature jump and pressure jump experiments and modeling; zebrafish and bacterial swimming behavior; protein-RNA interactions in live cells.

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Hammes-Schiffer, Sharon

Our research centers on the development and application of theoretical and computational methods for describing chemical reactions in condensed phases and at interfaces.

Hergenrother paul 02
Hergenrother, Paul

Computational and structure-based design of enzyme inhibitors; explorations of small molecule-RNA binding

Huang raven 02
Huang, Raven

Functional and structural characterization of protein enzymes involved in RNA modification and editing, site-specific RNA cleavage, and RNA repair

Jin, Hong

We are pursuing the molecular understanding of translation and its regulation using biochemical, genomic, and biophysical methods with an emphasis on macromolecule crystallography.

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Kong, Hyun Joon

Design of bioinspired materials, design of synthetic extracellular matrix; engineering of stem cell niches, FRET analysis of cell-ECM interaction; FRET analysis of biomolecular interaction; vascular/bone tissue engineering

Kraft mary
Kraft, Mary

Development of chemical imaging techniques to visualize the distribution of different components in cell membranes, and to understand how cell membrane structure and composition relates to disease progression

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Kuehn, Seppe

The Kuehn lab studies microbial ecology and evolution using model organisms in the laboratory

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Kuhlman, Thomas

Quantitative biology of gene regulation, intracellular diffusion of proteins, and the biophysical consequences of genome organization

Leckband, Deborah

Molecular Mechanisms of Cell Adhesion; Cell Engineering; Molecular force movements; structure; proteins; electrostatics; biomembranes

Lu, Ting

Gene circuits design and construction; mathematical modeling of bacterial gene regulation; development of synthetic microbial consortia; probiotic bacteria for therapeutic applications.

Lu yi
Lu, Yi

Rational design and directed evolution of proteins and catalytic DNA/RNAs and their applications in biocatalysis, sensing, imaging and drug delivery.

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Luthey-Schulten, Zaida

Signalling Networks in Protein: RNA Complexes; Protein: Protein and Protein: RNA Docking; Course-Grained Models of in vivo Cell Processes; Origins of the Genetic Code; Evolution of Translation; and VMD/MultiSeq: Evolutionary Analysis Software

Martinis, Susan

Molecular mechanisms of aminoacyl-tRNA synthetases and group I intron splicing; fidelity of protein synthesis

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Maslov, Sergei

I work on evolutionary and systems biology and carry out computational modeling of complex biological systems ranging from genome evolution and biomolecular networks to ecosystem dynamics. I am a statistical physicist by training so that in my research I often use physics-based modeling techniques. I particularly love simple-yet-rich "bottom down" models.

Nair, Satish

X-ray crystallography, enzymology, DNA replication

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Nelson, Mark

Neural information processing, neural basis of behavior, adaptive signal processing in the electric sense

Oldfield, Eric

Protein structure determination; design of novel drug molecules to kill parasitic protozoa causing malaria, sleeping sickness & opportunistic infections of immunocompromised individuals

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Olsen, Gary

The functions, evolutionary histories and structures of genes and proteins in Archaea

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Pogorelov, Taras

Application and development of computational and theoretical methods to study biological macromolecules using frameworks of molecular dynamics, quantum chemistry, and molecular evolution. Current emphasis is on the membrane-associated phenomena, membrane-protein interactions, and protein folding.

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Procko, Erik

The Procko lab combines molecular evolution with deep sequencing to determine the fitness landscapes of mammalian transmembrane proteins.

Rienstra, Chad

Fundamental studies of biomolecular structure and dynamics. Interactions of lipids, proteins and drugs. NMR technology development, including experimental and computational methods. Applications to Parkinson’s disease, blood clotting disorders, and systemic fungal infections.

Schroeder, Charles

Development of novel tools for single cell and biomolecule analysis, including, bio-inspired materials, hydrodynamic trapping, gene network dynamics, and synthetic biology

Schulten, Klaus

(Deceased 10/31/16) Structure and function of supramolecular systems in the living cell; development of new algorithms and efficient computing tools for structural biology

Selvin, Paul

Use of novel forms of fluorescence, at both single-molecule and ensemble levels, to study actomyosin, ion channels, and other biomolecules

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Shukla, Diwakar

Understanding behavior of key cellular signaling proteins involved in cancer for drug design & development; stress and energy signaling enzymes in plants, etc.

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Silverman, Scott

Our laboratory's focus is the development, characterization, and application of DNA as a catalyst (enzyme).

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Sinha, Saurabh

Computational models of gene regulatory sequences and their evolution

Sligar, Stephen

Structure-function relationships in protein and nucleic acid systems

Tajkhorshid, Emad

Computational studies of transport of molecules across biological membrane; structure-function relationship of membrane channels and transporters; Lipid-mediated regulation of binding and function of peripheral proteins

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Zhang, Kai

Development of imaging and optogenetic methods to delineate molecular mechanisms underlying cell fate determination; analysis of disrupted protein trafficking in neurodegenerative disorders.

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Zhang, Yang

Far-from-equilibrium systems; Extreme properties of liquids; Glassy, jammed, and kinetically trapped soft matter; Self-healing soft robotics; Long timescale phenomena and rare events; Atomistic modeling and simulation; Neutron and X-ray scattering

Zhao, Huimin

Development and application of synthetic biology tools to address society's most daunting challenges in human health and energy, and investigation of the fundamental aspects of enzyme catalysis, cell metabolism, and gene regulation

Zimmerman, Steven

Discovery of drugs that target DNA and RNA, development of synthetic organic and polymer-based drug and cell delivery agents, and new fluorescent probes