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Claudio F Grosman

Grossman claudio 02

Professor

grosman@illinois.edu

452A Burrill Hall, MC-114
Office: (217) 244-1736
Lab: (217) 333-1405
Fax: (217) 333-1133

Department of Molecular and Integrative Physiology
University of Illinois
524 Burrill Hall
407 S Goodwin Ave
Urbana, IL 61801

Lab Page

My laboratory is broadly interested in the relationship between structure and function in neurotransmitter-gated ion channels, with special emphasis on the Cys-loop superfamily of synaptic receptor-channels. Our main tools are single-channel and ensemble electrophysiology, and protein-engineering techniques.

Research Interests


My laboratory is broadly interested in the relationship between structure and function in neurotransmitter-gated ion channels, with special emphasis on the Cys-loop superfamily of synaptic receptor-channels. Our main tools are single-channel and ensemble electrophysiology, and protein-engineering techniques. Some of the particular issues we have been working on lately are:

Quantitative characterization of fundamental properties of neurotransmitter-gated ion channels such as rate and equilibrium constants of ligand binding in the closed and open states. Quantitative understanding of the different phenomena that contribute to the kinetics of the postsynaptic-current decay under physiological and pathological conditions. Linear free-energy relationships and the chemical dynamics of the closed to open conformational change. Relationship between structure and electrostatics of the pore domain.

Education

B.S./M.Sc., 1991, University of Buenos Aires, Argentina
Ph.D., 1996, University of Buenos Aires, Argentina
Postdoc., 1997-2002, State University of New York at Buffalo