Quantitative biology of gene regulation, intracellular diffusion of proteins, and the biophysical consequences of genome organization
My research involves the interplay of theoretical physics and in vivo experimental biology. My experimental work is primarily in the model bacterium E. coli, as its fundamental biological processes and their components are sufficiently well understood to allow their theoretical description to be tractable. We aim to combine cutting-edge single molecule microscopy and quantitative gene expression measurements to inform the construction of theoretical models describing the interaction of transcription factors (TFs) and other proteins with DNA in living cells, and then use these theoretical models to motivate further experiments.
B.A., 2000, Ball State University (Physics, Genetics, Cellular and Molecular Biology)
M.S., 2002, University of California at San Diego (Physics)
Ph.D., 2007, University of California at San Diego (Physics)
Postdoc., 2008-2012, Department of Molecular Biology, Princeton University
Alfred P Sloan Research Fellow 2015
NIH Ruth L Kirschstein National Research Service Award,